Eosinophilic Esophagitis

Eosinophilic Esophagitis (EoE) is a chronic, immune-mediated disorder. EoE symptoms can overlap with symptoms of a condition called gastroesophageal reflux disease (GERD).

Patients with EoE experience symptoms described as:

feeling like food or liquid is moving slowly
feeling food or liquid going down
food getting stuck in the esophagus
acid reflux, chest pain, nausea, vomiting
failure to thrive (children), regurgitation and esophageal strictures.

It occurs in approximately 1 in 10,000 people and affects people of all age groups, with males being affected more frequently. EOE is associated with food allergies or other allergens, causing eosinophils (type of white blood cell) to migrate from the bone marrow (via blood) and settle in the esophagus causing inflammation to the esophagus. No one knows exactly why EoE occurs. People with EoE tend to have allergic conditions such asthma, seasonal allergies, allergic rhinitis, and eczema.

Click on the drop-down below to see the criteria for each location.

Or sign up at the bottom of this page, and our office will call you!

Jacksonville Borland Groover Study (CLDX)

Jacksonville Borland Groover Study (CLDX)

For Clinicaltrials.gov information, click here.

For more information call
(904) 730-0166
Or sign up below, and our friendly staff will call you!

Inverness Study (CLEG)

Inverness Study (CLEG)

We are conducting a clinical trial for people who have active EoE.

This study will evaluate an investigational drug in adults with EoE to see how it reacts with a group of enzymes in the body called CYP (also known as cytochrome P450) that break down drugs.

The drug-drug interaction study will examine if there are any changes in CYP activity when the study drug and 5 selected approved drugs are given together. The study drug is a biologic agent, called a monoclonal antibody, and will be administered once a week for 17 weeks during the study.

This study will also evaluate whether the study drug helps the symptoms of EoE, such as trouble swallowing.

You may be eligible to participate if you:

Are 18 – 75 years old
Weigh at least 40 kg (88.2 lbs.)
Have a diagnosis of eosinophilic esophagitis and active symptoms
Are willing and able to receive weekly injections
Used or are using proton-pump inhibitor medications but still have symptoms (these are medications used for EoE, heartburn, or indigestion, such as omeprazole [Prilosec], lansoprazole [Prevacid], esomeprazole [Nexium])

Volunteers must be able to complete some overnight stays at our clinic for this study. There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and study-related medical exams at no cost. Study participants receive payment for each study visit they attend to reimburse for their time. No health insurance is required to participate.

For more information call

(352) 341-2100

Or sign up below, and our friendly staff will call you!

Click here to read informational articles about eosinophilic esophagitis.