Eosinophilic Esophagitis

Title:

Description:

Eosinophilic Esophagitis


Eosinophilic Esophagitis (EoE) is a chronic, immune-mediated disorder. EoE symptoms can overlap with symptoms of a condition called gastroesophageal reflux disease (GERD).

Patients with EoE experience symptoms described as:

  • feeling like food or liquid is moving slowly
  • feeling food or liquid going down
  • food getting stuck in the esophagus
  • acid reflux, chest pain, nausea, vomiting
  • failure to thrive (children), regurgitation and esophageal strictures.

It occurs in approximately 1 in 10,000 people and affects people of all age groups, with males being affected more frequently. EOE is associated with food allergies or other allergens, causing eosinophils (type of white blood cell) to migrate from the bone marrow (via blood) and settle in the esophagus causing inflammation to the esophagus. No one knows exactly why EoE occurs.  People with EoE tend to have allergic conditions such asthma, seasonal allergies, allergic rhinitis, and eczema.

If you are interested in a research study for Eosinophilic Esophagitis, sign up below!

Qualified volunteers may receive at no cost:

  • investigational medication
  • study-related care from a local doctor
  • possible compensation
Health insurance isn’t required to participate.
Ask your doctor or contact our clinic for more information.

For more information, call one of the offices below.

Or sign up below and we will contact you!



  • Jacksonville Borland Groover Study (CROSSING)
Jacksonville Borland Groover Study (CROSSING)

We are conducting a new clinical trial for people with Eosinophilic Esophagitis (EoE). The clinical trial is investigating tezepelumab – an investigational antibody drug. Tezepelumab has a new and unique action in the body. It stops a chemical produced in the body called thymic stromal lymphopoietin (TSLP). TSLP is increased in some people with EoE and causes inflammation. By blocking TSLP, researchers believe that tezepelumab will reduce inflammation in the esophagus and improve swallowing symptoms for patients with EoE.

You may be eligible to participate if you:

  • Are 12 – 80 years old
  • Have a diagnosis of EoE confirmed by an upper endoscopy (EGD) and esophageal biopsy
  • Weigh at least 40 kg (88.2 lbs.)
  • Have an average of at least 2 episodes of swallowing difficulties (dysphagia) per week.

There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and study-related medical exams at no cost and a stipend for time and travel. No health insurance is required to participate.

 

For more information call

(904) 680-0871

Or sign up below, and our friendly staff will call you!


  • St. Augustine Study (CROSSING)
St. Augustine Study (CROSSING)

We are conducting a new clinical trial for people with Eosinophilic Esophagitis (EoE). The clinical trial is investigating tezepelumab – an investigational antibody drug. Tezepelumab has a new and unique action in the body. It stops a chemical produced in the body called thymic stromal lymphopoietin (TSLP). TSLP is increased in some people with EoE and causes inflammation. By blocking TSLP, researchers believe that tezepelumab will reduce inflammation in the esophagus and improve swallowing symptoms for patients with EoE.

You may be eligible to participate if you:

  • Are 12 – 80 years old
  • Have a diagnosis of EoE confirmed by an upper endoscopy (EGD) and esophageal biopsy
  • Weigh at least 40 kg (88.2 lbs.)
  • Have an average of at least 2 episodes of swallowing difficulties (dysphagia) per week.

There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and study-related medical exams at no cost and a stipend for time and travel. No health insurance is required to participate.

 

For more information call

(904) 209-0043

Or sign up below, and our friendly staff will call you!


  • Inverness Study (CROSSING)
Inverness Study (CROSSING)

We are conducting a new clinical trial for people with Eosinophilic Esophagitis (EoE). The clinical trial is investigating tezepelumab – an investigational antibody drug. Tezepelumab has a new and unique action in the body. It stops a chemical produced in the body called thymic stromal lymphopoietin (TSLP). TSLP is increased in some people with EoE and causes inflammation. By blocking TSLP, researchers believe that tezepelumab will reduce inflammation in the esophagus and improve swallowing symptoms for patients with EoE.

You may be eligible to participate if you:

  • Are 12 – 80 years old
  • Have a diagnosis of EoE confirmed by an upper endoscopy (EGD) and esophageal biopsy
  • Weigh at least 40 kg (88.2 lbs.)
  • Have an average of at least 2 episodes of swallowing difficulties (dysphagia) per week.

There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and study-related medical exams at no cost and a stipend for time and travel. No health insurance is required to participate.

 

For more information call

(352) 341-2100

Or sign up below, and our friendly staff will call you!


  • Inverness Study (CLEG)
Inverness Study (CLEG)

We are conducting a clinical trial for people who have active EoE.

This study will evaluate an investigational drug in adults with EoE to see how it reacts with a group of enzymes in the body called CYP (also known as cytochrome P450) that break down drugs.

The drug-drug interaction study will examine if there are any changes in CYP activity when the study drug and 5 selected approved drugs are given together. The study drug is a biologic agent, called a monoclonal antibody, and will be administered once a week for 17 weeks during the study.

This study will also evaluate whether the study drug helps the symptoms of EoE, such as trouble swallowing.

You may be eligible to participate if you:

  • Are 18 – 75 years old
  • Weigh at least 40 kg (88.2 lbs.)
  • Have a diagnosis of eosinophilic esophagitis and active symptoms
  • Are willing and able to receive weekly injections
  • Used or are using proton-pump inhibitor medications but still have symptoms (these are medications used for EoE, heartburn, or indigestion, such as omeprazole [Prilosec], lansoprazole [Prevacid], esomeprazole [Nexium])

Volunteers must be able to complete some overnight stays at our clinic for this study. There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and study-related medical exams at no cost. Study participants receive payment for each study visit they attend to reimburse for their time.  No health insurance is required to participate.

 For more information call

(352) 341-2100

Or sign up below, and our friendly staff will call you!



Eosinophilic Esophagitis research is enrolling at:


St. Johns Center for Clinical Research
100 Whetstone Place,
Suites 300 – 301,
St. Augustine, FL 32086

(904) 209-0043



ENCORE Borland Groover Clinical Research
4800 Belfort Road, Suite 301
Jacksonville, FL 32256
(904) 680-0871



Nature Coast Clinical Research – Inverness
411 West Highland Boulevard
Inverness, FL 34452
(352) 341-2100



BELOW ARE HIDDEN ROWS

Fleming Island Center for Clinical Research
1679 Eagle Harbor Parkway
Suite D, 2nd Floor Fleming Island, FL 32003
(904) 621-0390



Jacksonville Center for Clinical Research
4085 University Blvd., South
Suite 1
Jacksonville, FL 32216
(904) 730-0166



St. Johns Center for Clinical Research
100 Whetstone Place,
Suites 300 – 301,
St. Augustine, FL 32086

(904) 209-0043



ENCORE Borland Groover Clinical Research
4800 Belfort Road, Suite 301
Jacksonville, FL 32256
(904) 680-0871



Westside Center for Clinical Research
810 Lane Avenue South
Jacksonville, FL 32205
(904) 693-1490



Nature Coast Clinical Research – Inverness
411 West Highland Boulevard
Inverness, FL 34452
(352) 341-2100



Nature Coast Clinical Research – Crystal River
6122 West Corporate Oaks Drive
Crystal River, FL 34429
(352) 861-1865



Learn More

If you want us to contact you about our research studies call (904) 730-0166 or sign up below!

Category
Inverness, Jacksonville (Borland Groover), St. Augustine
Encore logo

As a proven clinical research organization, we take every precaution to ensure the safety of and maximize the value for our research volunteers. Qualified doctors, nurses and study coordinators on staff provide support and care throughout the research trial. Participation is always voluntary. We appreciate the time and effort that research volunteers bring to this important process.

Copyright 2023 ENCORE Research Group