Heart Failure with Reduced Ejection Fraction

Heart failure is a condition where the heart can’t pump well enough to deliver oxygen to the organs effectively. Ejection fraction is a term used to describe the amount of blood pumped out compared with the total blood the heart can hold. In a healthy heart, 50-70% of blood is ejected with each heartbeat.
We are conducting a clinical research study for people who have heart failure with a reduced ejection fraction (<50%). This study will evaluate the safety and tolerability of a new investigational drug.
You may be eligible if you:
- Are between 18 and 80 years old
- Have heart failure
- Have a left ventricular ejection fraction (LVEF) of <50%
- Have been taking a stable dose of sacubitril/valsartan (Entresto) for at least 4 weeks.
- Have been taking a stable dose of a beta blocker for at least 4 weeks.
- Examples of beta blockers:
- Acebutolol
- Atenolol (Tenormin)
- Bisoprolol (Zebeta)
- Metoprolol (Lopressor, Toprol XL)
- Nadolol (Corgard)
- Nebivolol (Bystolic)
- Propranolol (Inderal, InnoPran XL)
- Examples of beta blockers:
Volunteers must be able to complete multiple overnight stays at our phase 1 clinic for this study. There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and study-related medical exams at no cost, along with a stipend for time and travel. No health insurance is required to participate.
For more information call:
(904) 730-0166 (Jacksonville)
(352) 341-2100 (Inverness)
This research is enrolling at:
Jacksonville Center for Clinical Research
4085 University Blvd., South
Suite 1
Jacksonville, FL 32216
(904) 730-0166
Nature Coast Clinical Research – Inverness
411 West Highland Boulevard
Inverness, FL 34452
(352) 341-2100
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If you want us to contact you about our research studies call (904) 730-0166 or sign up below!
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