Heart Failure

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Heart Failure

Heart Failure

Heart failure is a serious medical condition where the heart cannot effectively deliver enough oxygenated blood to the organs. It affects millions of Americans and may have debilitating symptoms including edema, shortness of breath, systemic inflammation, and reduced quality of life. 


For more information, call:

(904) 730-0166 (Jacksonville)
(904) 209-0043 (St. Augustine)
(352) 563-1865 (Crystal River)
(352) 341-2100 (Inverness)

Click on the drop-down below to see the criteria for each location. 

Or sign up below, and our office will call you!


  • Jacksonville – Study (HERMES)
  • Jacksonville – Study (R2R)
  • St. Augustine – Study (HFrEF)
  • St. Augustine – Study (HERMES)
  • Crystal River – Study (HERMES)
  • Inverness – Study (R2R)
Jacksonville – Study (HERMES)

Heart Failure Clinical Research

Heart failure is a serious medical condition where the heart cannot effectively deliver enough oxygenated blood to the organs. It affects millions of Americans and may have debilitating symptoms including edema, shortness of breath, systemic inflammation, and reduced quality of life.

Even with the best available treatment, there is still a risk of serious complications. Reducing the amount of systemic inflammation may increase health outcomes for people with heart failure. We are conducting a research study for people with heart failure that will evaluate the effectiveness of an investigational drug on cardiovascular health outcomes.

You may be eligible if you:

  • Are 18 or older
  • Have heart failure
  • Have a preserved or mildly reduced ejection fraction (LVEF >40%) documented by echocardiography within the past 12 months

There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and study-related medical exams at no cost and a stipend for time and travel. No health insurance is required to participate.

 For more information call

(904) 730-0166

Or sign up below, and our friendly staff will call you!

Jacksonville – Study (R2R)

Worsening Heart Failure Research 

Are you or someone you know currently experiencing swelling in the legs or feet due to worsening heart failure? If you need an increase in your diuretics to address your symptoms, you may be eligible to participate in our heart failure clinical research study.  

Jacksonville Center for Clinical Research is conducting a research study that will evaluate an investigational medication for people with Worsening Heart Failure. 

You may be eligible to participate if you:

  • Are 18+ years old 
  • Are currently taking heart failure medication 
  • Have been hospitalized for heart failure within the past 12 months  
  • Need an increase in your diuretics (oral or IV) 
  • Have at least two of the following symptoms of worsening heart failure congestion:  
    • Dyspnea (Difficult or labored breathing)  
    • Orthopnea (shortness of breath that occurs while lying flat and is relieved by sitting or standing)  
    • Fatigue (a feeling of constant exhaustion, burnout or lack of energy)  
    • Jugular venous distention (when the vein that runs down the right side of the neck is swollen)  
    • Rales (Small clicking, bubbling, or rattling sounds in the lungs)  
    • Edema (swelling caused by too much fluid trapped in the body’s tissues) 

There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication, medical exams at no cost, and a stipend for time and travel. No health insurance is required to participate. 

 For more information call 

(904) 730-0166 

Or sign up below, and our friendly staff will call you! 

St. Augustine – Study (HFrEF)

Heart Failure Research

With heart failure, the heart becomes incapable of pumping enough blood to meet the needs of the entire body. This condition affects millions of Americans and can limit how much ordinary physical activity people can perform. Despite long-term trends, recent data shows that the rate of heart failure is on the rise for many Americans. Clinical research is needed to address this growing concern. 

 St. Johns Center for Clinical Research is conducting a research study for volunteers to evaluate an investigational medication for people with Heart Failure and a reduced ejection fraction. 

You may be eligible to participate if you: 

  • Are 18+ years old 
  • Have symptoms of heart failure 
    • Shortness of breath 
    • Fatigue 
    • Chest pain 
  • Have an Ejection Fraction (LVEF) less than 50% 
  • Have been on stable ACE inhibitor, ARB medication, or Entresto for at least 1 month 

There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and medical exams at no cost, along with a stipend for time and travel. No health insurance is required to participate. 

For more information call

(904) 209-0043

Or sign up below, and our friendly staff will call you!

St. Augustine – Study (HERMES)

Heart Failure Clinical Research

Heart failure is a serious medical condition where the heart cannot effectively deliver enough oxygenated blood to the organs. It affects millions of Americans and may have debilitating symptoms including edema, shortness of breath, systemic inflammation, and reduced quality of life. Even with the best available treatment, there is still a risk of serious complications. Reducing the amount of systemic inflammation may increase health outcomes for people with heart failure. We are conducting a research study for people with heart failure that will evaluate the effectiveness of an investigational drug on cardiovascular health outcomes.

You may be eligible if you:

  • Are 18 or older
  • Have heart failure
  • Have a preserved or mildly reduced ejection fraction (LVEF >40%) documented by echocardiography within the past 12 months

There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and study-related medical exams at no cost and a stipend for time and travel. No health insurance is required to participate. 

For more information call

(904) 209-0043

Or sign up below, and our friendly staff will call you!

Crystal River – Study (HERMES)

Heart Failure Clinical Research

Heart failure is a serious medical condition where the heart cannot effectively deliver enough oxygenated blood to the organs. It affects millions of Americans and may have debilitating symptoms including edema, shortness of breath, systemic inflammation, and reduced quality of life. Even with the best available treatment, there is still a risk of serious complications. Reducing the amount of systemic inflammation may increase health outcomes for people with heart failure. We are conducting a research study for people with heart failure that will evaluate the effectiveness of an investigational drug on cardiovascular health outcomes.

You may be eligible if you:

  • Are 18 or older
  • Have heart failure
  • Have a preserved or mildly reduced ejection fraction (LVEF >40%) documented by echocardiography within the past 12 months

There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and study-related medical exams at no cost and a stipend for time and travel. No health insurance is required to participate. 

For more information call

(352) 341-2100

Or sign up below, and our friendly staff will call you!

Inverness – Study (R2R)

Worsening Heart Failure Research 

Are you or someone you know currently experiencing swelling in the legs or feet due to worsening heart failure? If you need an increase in your diuretics to address your symptoms, you may be eligible to participate in our heart failure clinical research study.  

Nature Coast Clinical Research – Inverness is conducting a research study that will evaluate an investigational medication for people with Worsening Heart Failure. 

You may be eligible to participate if you:

  • Are 18+ years old 
  • Are currently taking heart failure medication 
  • Have been hospitalized for heart failure within the past 12 months  
  • Need an increase in your diuretics (oral or IV) 
  • Have at least two of the following symptoms of worsening heart failure congestion:  
    • Dyspnea (Difficult or labored breathing)  
    • Orthopnea (shortness of breath that occurs while lying flat and is relieved by sitting or standing)  
    • Fatigue (a feeling of constant exhaustion, burnout or lack of energy)  
    • Jugular venous distention (when the vein that runs down the right side of the neck is swollen)  
    • Rales (Small clicking, bubbling, or rattling sounds in the lungs)  
    • Edema (swelling caused by too much fluid trapped in the body’s tissues) 

There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication, medical exams at no cost, and a stipend for time and travel. No health insurance is required to participate. 

 For more information call 

(352) 341-2100 

Or sign up below, and our friendly staff will call you! 



This research is enrolling at:


Jacksonville Center for Clinical Research
4085 University Blvd., South
Suite 1
Jacksonville, FL 32216
(904) 730-0166



St. Johns Center for Clinical Research
100 Whetstone Place,
Suites 300 – 301,
St. Augustine, FL 32086

(904) 209-0043



Nature Coast Clinical Research – Crystal River
6122 West Corporate Oaks Drive
Crystal River, FL 34429
(352) 563-1865



Nature Coast Clinical Research – Inverness
411 West Highland Boulevard
Inverness, FL 34452
(352) 341-2100



BELOW ARE HIDDEN ROWS

Fleming Island Center for Clinical Research
1679 Eagle Harbor Parkway
Suite D, 2nd Floor Fleming Island, FL 32003
(904) 621-0390



Jacksonville Center for Clinical Research
4085 University Blvd., South
Suite 1
Jacksonville, FL 32216
(904) 730-0166



St. Johns Center for Clinical Research
100 Whetstone Place,
Suites 300 – 301,
St. Augustine, FL 32086

(904) 209-0043



ENCORE Borland Groover Clinical Research
4800 Belfort Road, Suite 301
Jacksonville, FL 32256
(904) 680-0871



Westside Center for Clinical Research
810 Lane Avenue South
Jacksonville, FL 32205
(904) 693-1490



Nature Coast Clinical Research – Inverness
411 West Highland Boulevard
Inverness, FL 34452
(352) 341-2100



Nature Coast Clinical Research – Crystal River
6122 West Corporate Oaks Drive
Crystal River, FL 34429
(352) 861-1865



Learn More

If you want us to contact you about our research studies call (904) 730-0166 or sign up below!

Category
Crystal River, Inverness, Jacksonville (University Blvd.), St. Augustine
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As a proven clinical research organization, we take every precaution to ensure the safety of and maximize the value for our research volunteers. Qualified doctors, nurses and study coordinators on staff provide support and care throughout the research trial. Participation is always voluntary. We appreciate the time and effort that research volunteers bring to this important process.

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