Heart Failure with Reduced Ejection Fraction



Heart Failure with Reduced Ejection Fraction

Heart failure is a condition where the heart can’t pump well enough to deliver oxygen to the organs effectively. Ejection fraction is a term used to describe the amount of blood pumped out compared with the total blood the heart can hold. In a healthy heart, 50-70% of blood is ejected with each heartbeat.

We are conducting a clinical research study for people who have heart failure with a reduced ejection fraction (<50%). This study will evaluate the safety and tolerability of a new investigational drug.

You may be eligible if you:

  • Are between 18 and 80 years old
  • Have heart failure
  • Have a left ventricular ejection fraction (LVEF) of <50%
  • Have been taking a stable dose of sacubitril/valsartan (Entresto) for at least 4 weeks.
  • Have been taking a stable dose of a beta blocker for at least 4 weeks.
    • Examples of beta blockers:
      • Acebutolol
      • Atenolol (Tenormin)
      • Bisoprolol (Zebeta)
      • Metoprolol (Lopressor, Toprol XL)
      • Nadolol (Corgard)
      • Nebivolol (Bystolic)
      • Propranolol (Inderal, InnoPran XL)

Volunteers must be able to complete multiple overnight stays at our phase 1 clinic for this study. There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and study-related medical exams at no cost, along with a stipend for time and travel. No health insurance is required to participate.

For more information call:
(904) 730-0166 (Jacksonville)
(352) 341-2100 (Inverness)

Or sign up below!

    This research is enrolling at:

    Jacksonville Center for Clinical Research
    4085 University Blvd., South
    Suite 1
    Jacksonville, FL 32216
    (904) 730-0166

    Nature Coast Clinical Research – Inverness
    411 West Highland Boulevard
    Inverness, FL 34452
    (352) 341-2100

    Learn More

    If you want us to contact you about our research studies call (904) 730-0166 or sign up below!

    Inverness, Jacksonville (University Blvd.)
    Encore logo

    As a proven clinical research organization, we take every precaution to ensure the safety of and maximize the value for our research volunteers. Qualified doctors, nurses and study coordinators on staff provide support and care throughout the research trial. Participation is always voluntary. We appreciate the time and effort that research volunteers bring to this important process.

    Copyright 2023 ENCORE Research Group