High Cholesterol



High Cholesterol


  • High Cholesterol with Heart Risk
  • High Cholesterol
High Cholesterol with Heart Risk

A Double-blind, Randomized, Placebo-controlled, Multicenter Study

Phase: 3

Inclusion Criteria:

  • Age: Adult subjects ≥ 50 (men) or ≥ 55 (women) to ˂ 80 years of age (either sex) and meeting lipid criteria
  • Low-density lipoprotein cholesterol (LDL) ≥ 90 mg/dL or non‑high-density lipoprotein cholesterol (non-HDL) ≥ 120 mg/dL
  • Evidence of at least one of the following at screening (without prior heart attack or stroke):
    • A. Significant coronary artery disease (CAD)
    • B. Significant atherosclerotic cerebrovascular disease
    • C. Significant peripheral arterial disease
    • D. Diabetes mellitus

There are additional criteria to meet in order to qualify for this research study. For more information contact us!

Study Location: Crystal River, Jacksonville

High Cholesterol

A Phase I Randomized, Single-blind, Placebo-controlled Study

Ages Eligible for Study:    18 Years to 65 Years

Inclusion Criteria:

  • Have a body mass index (BMI) between 25 and 40 kg/m2.
  • Have an LDL-C > 70 but < 200 mg/dL.
  • Subjects should be receiving moderate- or high-intensity statin therapy as defined by the American College of cardiology/American Heart Association (ACC/AHA) guideline on blood cholesterol management.

There are additional criteria to meet in order to qualify for this research study. For more information contact us!

Study Location: Jacksonville

If you or someone you know has High Cholesterol, call us today! We have research studies enrolling now.

No cost, and no health insurance is required to participate.
Ask your doctor or contact our clinic for more information.

For more information call:
(904) 730-0166
Or sign up below!

Informational Article:

  • PCSK9: The Real Problem Behind Cholesterol
PCSK9: The Real Problem Behind Cholesterol

Cholesterol has earned a bad reputation over the years. However, it is required by every part of your body for day to day functions. In fact, cholesterol is so important to daily function, that every cell in the body can make cholesterol from basic materials, except your eyelashes! So how do you reconcile these two completely different ideas? The cholesterol that circulates in your blood stream is the extra stuff that your body is trying to get rid of. This extra cholesterol is what can cause damage to arteries, heart disease, and increase your risk for stroke.

So, what is cholesterol? It is a type of waxy, fat-like substance, also called a lipid.  Since cholesterol is a fat, it can’t travel alone in the bloodstream. It would end up as useless globs (imagine bacon fat floating in a pot of water). To get around this problem, the body packages cholesterol and other lipids into minuscule protein-covered particles that mix easily with blood. These tiny particles, called lipoproteins (lipid plus protein), move cholesterol and other fats throughout the body.1

LDL (low-density lipoprotein) is considered the “bad”, unhealthy cholesterol that can build up in the arteries and form deposits called plaques.

HDL (high-density lipoprotein) is the “good”, healthy kind of cholesterol that transports excess LDL cholesterol to the liver to be removed from the body.

PCSK9 is a protein in our body that regulates the circulating levels of LDL “bad” cholesterol.  Decreasing the PCSK9 proteins in the body will reduce LDL levels and reduce the risk of heart attack and stroke.

There are currently two FDA approved medications that have been very successful in blocking the PCSK9 protein once it has been made.  They are Repatha and Praluent.  However, the medications are expensive and not approved for all patients under their insurance.

Scientists believe it would be even more powerful to prevent the PCSK9 protein from being made in the first place. Currently being studied are a new class of molecules called antisense oligonucleotides (ASO).  ASOs are pieces of DNA that short-circuit the production of PCSK9, resulting in reduced LDL levels and associated risks.

When you participate in a clinical research study, you gain access to these types of cutting-edge therapies at no cost and before the general population. Contact us to schedule a free consultation to see if you qualify for one of our clinical research studies. If you qualify for one of our clinical trials, your health will be closely monitored by our team of expert medical professionals throughout the trial.


  1. https://www.health.harvard.edu/heart-health/how-its-made-cholesterol-production-in-your-body

Cholesterol research is enrolling at:

Jacksonville Center for Clinical Research
4085 University Blvd., South
Suite 1
Jacksonville, FL 32216
(904) 730-0166

Nature Coast Clinical Research – Crystal River
6122 West Corporate Oaks Drive
Crystal River, FL 34429
(352) 861-1865

Learn More

If you want us to contact you about our research studies call (904) 730-0166 or sign up below!

Crystal River, Jacksonville
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As a proven clinical research organization, we take every precaution to assure the safety of and maximize the value for our research volunteers. Qualified doctors, nurses and study coordinators on staff provide support and care throughout the research trial. Participation is always voluntary. We appreciate the time and effort that research volunteers bring to this important process.

Copyright 2020 ENCORE Research Group