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April 28, 2020
Crohn's Disease

If you have Crohn’s Disease, you may qualify for one of our research studies.

Qualified volunteers may receive at no cost:

  • investigational medication
  • study-related care from a local doctor
  • possible compensation
Health insurance isn’t required to participate.
Ask your doctor or contact our clinic for more information.

Informational Articles:


  • Living with Crohn’s Disease Long Term
Living with Crohn’s Disease Long Term

Crohn’s disease is a chronic irritable bowel disease (IBD). In those with crohn’s disease, an abnormal immune system causes chronic inflammation in the digestive tract. IBD affects nearly 3 million Americans, and there is still no known cure.

Symptoms of Crohn’s Disease

 A person living with crohn’s disease can experience many symptoms and the severity can range from no pain at all to immobilizing. The symptoms include:

  • Diarrhea
  • Abdominal pain
  • Cramping
  • Weight Loss
  • Blood in Stools
  • Fatigue
  • Nausea and vomiting
  • No appetite
  • Anemia
  • Fever

Long-Term effects of Crohn’s Disease

Living with crohn’s disease can take its toll on the body long term. If left unmanaged, crohn’s disease can worsen and cause extreme pain and health concerns. Over time, crohn’s disease can cause severe damage to the GI tract. This can lead to:

  • Fistulas. When excessive inflammation causes ulcers to form on the intestine, a fistula can form. A fistula is when two parts of the intestine connect to form a tunnel to drain the pus from the infected area.
  • Intestinal Abscesses. This is caused by an excess of bacteria in the
  • Intestinal Blockages. This is a blockage that keeps food or liquid from passing through the small or large Symptoms can include severe abdominal pain, vomiting and inability to pass gas or stool.
  • Internal Bleeding. This internal bleeding is caused by tears in the bowel wall due to inflammation in the It is often the cause for diarrhea or bloody stool, a common symptom of crohn’s disease.

Crohn’s disease can be managed and those with the disease can live a very fulfilling life. The main goal of management is to treat the inflammation, which should reduce the severity of the symptoms and hopefully lead to long-term remission.

As mentioned, there is no known cure for crohn’s disease. The only way to find a cure and help those living with crohn’s disease is to participate in clinical trials to further research and hopefully, find a cure.

Resources: Centers for Disease Control and Prevention, Crohn’s and Colitis Foundation, Bladder and Bowel



Crohn’s Disease research is enrolling at:


ENCORE Borland Groover Clinical Research
4800 Belfort Road, Suite 301
Jacksonville, FL 32256
(904) 680-0871



Nature Coast Clinical Research – Inverness
411 West Highland Boulevard
Inverness, FL 34452
(352) 341-2100



Learn More

If you want us to contact you about our research studies call (904) 730-0166 or sign up below!


Throat-EOE.jpg

April 28, 2020
Throat EOE


    Eosinophilic Esophagitis (EoE) is a chronic, immune-mediated disorder. EoE symptoms can overlap with symptoms of a condition called gastroesophageal reflux disease (GERD).

    Patients with EoE experience symptoms described as:

    • feeling like food or liquid is moving slowly
    • feeling food or liquid going down
    • food getting stuck in the esophagus
    • acid reflux, chest pain, nausea, vomiting
    • failure to thrive (children), regurgitation and esophageal strictures.

    It occurs in approximately 1 in 10,000 people and affects people of all age groups, with males being affected more frequently. EOE is associated with food allergies or other allergens, causing eosinophils (type of white blood cell) to migrate from the bone marrow (via blood) and settle in the esophagus causing inflammation to the esophagus. No one knows exactly why EoE occurs.  People with EoE tend to have allergic conditions such asthma, seasonal allergies, allergic rhinitis, and eczema.

    We are conducting a clinical trial for people with Eosinophilic Esophagitis. The purpose of this study is to assess the safety and tolerability of a new oral investigational medication for Eosinophilic Esophagitis.

    Volunteers may be eligible if they:

    • Are aged 18 or older.
    • Have a diagnosis or presumed diagnosis of EOE which will be confirmed during the screening process.

    There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study related investigational medication, procedures and medical exams at no cost, as well as reimbursement for time and travel. No health insurance is required to participate.

    For more information call





      Eosinophilic Esophagitis research is enrolling at:


      ENCORE Borland Groover Clinical Research
      4800 Belfort Road, Suite 301
      Jacksonville, FL 32256
      (904) 680-0871



      Nature Coast Clinical Research – Inverness
      411 West Highland Boulevard
      Inverness, FL 34452
      (352) 341-2100



      Learn More

      If you want us to contact you about our research studies call (904) 730-0166 or sign up below!


      Gastroparesis-2.jpg

      April 28, 2020
      Gastroparesis

      If you have Gastroparesis, you may qualify for one of our studies.

      Qualified volunteers may receive at no cost:

      • investigational medication
      • study-related care from a local doctor
      • possible compensation
      Health insurance isn’t required to participate.
      Ask your doctor or contact our clinic for more information.




        Gastroparesis research is enrolling at:


        ENCORE Borland Groover Clinical Research
        4800 Belfort Road, Suite 301
        Jacksonville, FL 32256
        (904) 680-0871



        Learn More

        If you want us to contact you about our research studies call (904) 730-0166 or sign up below!


        GERD-heartburn.jpg

        April 11, 2022
        GERD heartburn


        Relief of Heartburn in Patients with NERD

        We are conducting a research study for people with heartburn symptoms caused by non-erosive gastroesophageal reflux disease, or NERD. This research study will evaluate the effectiveness and safety of an investigational medication for the potential treatment of NERD compared to a placebo.

        You may be eligible if you:

        • Are 18 years or older
        • Have been experiencing frequent heartburn for at least six months

        There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related investigational medication or placebo, and medical exams at no cost. Volunteers may also receive reimbursement for certain study assessments and travel. No health insurance is required to participate.

        For more information call:

        (904) 730-0166
        Or sign up, our office will call you!


        Informational Articles:

        • NERD – Non-Erosive Reflux Disease
        • The Effects of Long-Term GERD
        NERD – Non-Erosive Reflux Disease

        Chronic heartburn and acid reflux are symptoms of gastroesophageal reflux disease (GERD). This disease can result in the wearing away of the tube between the stomach and throat. When wearing away does not occur, a specific type of GERD occurs. This type is non-erosive reflux disease (NERD). 

        The rates of GERD in the US are very large, affecting 1 in 5 people. Most of those cases are actually the NERD type. This works out to 14% of Americans experiencing NERD. It affects men and women at equal rates, and in the USA rates are constant across racial lines. 

        Several factors can increase the chances of getting NERD. Your chances are increased with:

        • Age, peaking around 70 years old
        • Smoking
        • Drinking excessive coffee
        • Drinking excessive alcohol
        • Obesity
        • Eating large amounts of food
        • Eating fatty foods
        • Eating at night

        NERD does not destroy the esophagus, but comes with its own host of issues. Heartburn and irritation of the food tube define NERD, and are uncomfortable on their own. It can also cause chest pain, vomiting, asthma, coughs, and sleeping problems. Furthermore, a major class of GERD-targeting drugs are less effective on the non-erosive form, NERD. These drugs are called proton-pump-inhibitors.

        Proton pump inhibitors are the most effective medications for treating GERD. Major name-brand proton-pump-inhibitors include Prilosec, Protonix, Nexium, Prevacid, and several others. The generic names are omeprazole, pantoprazole, esomeprazole, and others. All of these work by reducing the stomach’s ability to make stomach acid, lowering its ability to burn. As a result, GERD is both less painful and less destructive to the esophagus.

        Several people experiencing NERD are resistant to proton-pump-inhibitors. There are several possible reasons. In some patients, high concentrations of stomach acid isn’t the cause of their issues. In fact, only around half of NERD patients have abnormal acid levels, so lowering stomach acid may not be helpful as a treatment. These patients may have acid reflux even when acid levels are normal. They may also have a particularly sensitive esophagus. This could result in the feeling of heartburn even with lower acid levels. These patients need new treatments to help manage NERD. With luck, a clinical trial will pave the way to widespread adoption of an effective treatment soon!

        The Effects of Long-Term GERD

        At some point in our lives we have all experienced acid reflux. Maybe it was after eating something spicy, or any acidic food like a tomato or certain dairy products and you felt a burning sensation in your throat. GERD, or gastroesophageal reflux disease is similar to acid reflux. GERD is a long-term condition where acid from your stomach overflows into the esophagus. If you experience acid reflux that occurs more than twice a week, your doctor may diagnose you with GERD.

        If you are experiencing these below symptoms more than twice a week, it may be time to see a doctor.

        • Heartburn after eating
        • Chest Pain (Please see a doctor if you are experiencing chest
          pain, especially coupled with shortness of breath, jaw pain or arm pain.
          You could be experiencing a heart attack).
        • Difficulty swallowing
        • Regurgitation of food or liquid
        • Feeling on having a lump in your throat

        Although GERD is a common condition affecting over 3 million
        Americans per year, if left untreated, it can lead to serious medical conditions.

        • Esophageal Stricture – which is the narrowing of the esophagus. Frequent backup of stomach acid into the esophagus can begin to cause significant damage causing scar tissue to form. The scar tissue can act as a barrier making it extremely difficult to swallow.
        • Esophageal Ulcer – or, in other words, an open sore in your esophagus. This happens when the stomach acid begins to wear down on the tissue causing sores which can bleed, cause pain and further increase difficulty swallowing.
        • Barrett’s Esophagus – This happens when there begins to be precancerous changes to the esophagus. These changes can cause an increased risk of esophageal cancer.

        With certain lifestyle changes and medication, GERD can be treated. However, more research is needed to understand why there is a steady increase in
        Americans with GERD.

        Currently, ENCORE Research Group has enrolling studies for GERD taking place in Crystal River and Jacksonville. Visit our Enrolling Studies page to see what’s enrolling at a research site near you.

        Source: Medical News Today, Medline Plus




          This research study is enrolling at:


          Nature Coast Clinical Research – Inverness
          411 West Highland Boulevard
          Inverness, FL 34452
          (352) 563-1865



          ENCORE Borland Groover Clinical Research
          4800 Belfort Road, Suite 301
          Jacksonville, FL 32256
          (904) 680-0871



          Learn More

          If you want us to contact you about our research studies call (904) 730-0166 or sign up below!


          Encore logo

          As a proven clinical research organization, we take every precaution to assure the safety of and maximize the value for our research volunteers. Qualified doctors, nurses and study coordinators on staff provide support and care throughout the research trial. Participation is always voluntary. We appreciate the time and effort that research volunteers bring to this important process.

          Copyright 2021 ENCORE Research Group