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Glaucoma-eye-drops.jpg

April 28, 2020
Glaucoma eye drops

If you or someone you know has Glaucoma, call us today! We have research studies enrolling now.

No cost, and no health insurance is required to participate.
Ask your doctor or contact our clinic for more information.

For more information call:
(904) 730-0166
Or sign up below!


  • Glaucoma: Too Much Aqueous Humor Is Nothing To Laugh At
  • Blindsided by Glaucoma?
Glaucoma: Too Much Aqueous Humor Is Nothing To Laugh At

The eye is a fragile and carefully balanced organ. At the very front of the eye is a fluid-filled chamber called the anterior chamber. This is located between the clear cornea at the front and the pupil, where light enters the rest of the eye. The fluid that fills this area is called the aqueous humor. The aqueous humor is critically important for cleaning and bringing nutrients to the lens. It is like a clear version of blood. Another key job the aqueous humor performs is maintaining eye pressure.

The pressure in the eye needs to be maintained within a very specific range (12-22 mm Hg). Aqueous humor continuously flows through the front of the eye at a very slow rate (like blood, but slower). When the flow rate out of the eye gets disrupted, eye pressure increases.

Doctors call high eye pressure ocular hypertension. The major characteristic is increased eye pressure without other symptoms. When eye pressure causes damage to the optic nerve, we call it glaucoma. Glaucoma can occur in two ways, closed angle or open angle. Closed angle is sudden and a medical emergency. Open angle makes up almost all cases of glaucoma and is gradual in onset. Typical symptoms of open angle glaucoma are vision problems in the middle of sight. These can include trouble with reading, seeing faces, walking, and driving. Both types will cause permanent blindness if untreated.

Open angle glaucoma can happen to anyone, but is much more common with adults over 60 years old. Most cases are females, and black and Asian populations experience higher rates of the condition. There are several underlying reasons for open-angle glaucoma: vascular, anatomical, genetic, or immune. Because of this wide spread of causes, there are several risk factors:

  • Genetics / Family history
  • Diabetes
  • Extreme nearsightedness
  • Hypertension
  • Eye injury
  • Eye abnormalities
  • Steroid use
  • Smoking

Several treatments are available for glaucoma. These include surgical and medication-based treatments, and surgically implanted medications. The goal of all treatments is to increase the flow of fluid out, decrease the amount of fluid coming in, or to decrease the volume of the anterior chamber. Medications are quite effective when taken properly. Unfortunately, fewer than one third of patients adhere to doctor recommendations for glaucoma eye drops after a year. This is in spite of the condition being progressive in nature and leading to blindness. Effective implanted medication delivery systems may provide better outcomes for patients.

To get involved in the latest glaucoma research, contact our Nature Coast Crystal River office.

Sources:

Allison, K., Patel, D., & Alabi, O. (2020). Epidemiology of glaucoma: the past, present, and predictions for the future. Cureus12(11).

Li, F., Huang, W., & Zhang, X. (2018). Efficacy and safety of different regimens for primary open‐angle glaucoma or ocular hypertension: A systematic review and network meta‐analysis. Acta ophthalmologica96(3), e277-e284.

Robin, A. L., & Muir, K. W. (2019). Medication adherence in patients with ocular hypertension or glaucoma. Expert Review of Ophthalmology14(4-5), 199-210.

Blindsided by Glaucoma?

Glaucoma is a common eye disease that can gradually steal your vision. The term glaucoma refers to a collection of eye diseases that damage the optic nerve. This damage can lead to permanent vision loss or even total blindness. Glaucoma is considered a major cause of blindness in the general population.

A major concern is that glaucoma often presents no early symptoms but continues to cause gradual, un-reversable damage. In most cases, glaucoma is diagnosed in people who are older than 40 but can still develop at an earlier age. An estimated 3.54% of adults between 40 and 80 years have been diagnosed with some type of glaucoma.

Causes Of Glaucoma

In most types of glaucoma, the eye’s drainage system becomes clogged so the intraocular fluid cannot drain. As the fluid builds up, it causes pressure to build inside the eye.  High pressure damages the sensitive optic nerve and results in vision loss.

People are more likely to develop glaucoma if they:

  • Are over the age of 40
  • Have a family history of glaucoma
  • Have high blood pressure, heart disease, diabetes, or sickle cell anemia
  • Are of African American, Irish, Russian, Japanese, Hispanic, Inuit, or Scandinavian descent
  • Take certain steroid medications such as prednisone
  • Have had an injury to your eye or eyes
  • Have high eye pressure (ocular hypertension)

Current Treatments Available

Unfortunately, there is not currently a cure for glaucoma. However, there are several therapies that can help reduce eye pressure and the rate of damage to the optic nerve. Current approved treatment options for glaucoma include eyedrops, oral medications, laser surgery, or microsurgery.

Clinical Research Advancements

New clinical trials for glaucoma are focused on more innovative ways to treat the disease. Researchers are studying everything from electric current stimulation to slow release eye implants to help find relief for patients with glaucoma.

You can help advance medical research by participating in a clinical trial! Contact any of our offices to see what clinical trials are enrolling today.



This research study is enrolling at:


Nature Coast Clinical Research – Crystal River
6122 West Corporate Oaks Drive
Crystal River, FL 34429
(352) 563-1865



Learn More

If you want us to contact you about our research studies call (904) 730-0166 or sign up below!


Heart-stethoscope.jpg

May 4, 2022


If you or someone you know has heart failure, call us today! We have multiple cardiovascular research studies enrolling now.

No cost, and no health insurance is required to participate.
Ask your doctor or contact our clinic for more information.

For more information call:
(904) 730-0166
Or sign up below!




    This research is enrolling at:


    Jacksonville Center for Clinical Research
    4085 University Blvd., South
    Suite 1
    Jacksonville, FL 32216
    (904) 730-0166



    Nature Coast Clinical Research – Crystal River
    6122 West Corporate Oaks Drive
    Crystal River, FL 34429
    (352) 563-1865



    St. Johns Center for Clinical Research
    100 Whetstone Place,
    Suites 300 – 301,
    St. Augustine, FL 32086

    (904) 209-0043



    Learn More

    If you want us to contact you about this research study call (904) 730-0166 or sign up below!


    Sciatica-2.png

    November 17, 2023

    Click on the drop-down below to see the criteria for each location. 

    Or sign up below, and our office will call you!



    • Fleming Island Study
    • Jacksonville Study
    • Nature Coast Crystal River Study
    Fleming Island Study

    Painful Lumbosacral Radiculopathy (Sciatica) 

     Painful lumbosacral radiculopathy, commonly known as sciatica, is a specific kind of low back pain due to inflammation or pinching of a spinal nerve. It presents as electric, burning, and/or sharp pain in the lower back which may radiate into the legs. Researchers are currently investigating a method of targeting lumbosacral radiculopathy pain by preventing peripheral nerves from sending pain signals.   

     

    Fleming Island Center for Clinical Research is conducting a research study that will evaluate an investigational medication for Painful Lumbosacral Radiculopathy (sciatica). 

     

    You may be eligible to participate if you: 

    • Are 18-70 years old 
    • Are over 100 pounds with a BMI under 40 
    • Have been diagnosed with painful lumbosacral radiculopathy (sciatica) for at least 3 months; with leg pain worse than back pain 
    • Have not used opioids for chronic pain in the last 3 months or taken opioids for more than 7 days for acute pain in the past 3 months. 

     

    There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and medical exams at no cost, along with compensation for study-related time and reimbursement for travel. No health insurance is required to participate. 

    For more information call 

    (904) 621-0390 

    Or sign up below, and our friendly staff will call you! 

    Jacksonville Study

    Painful Lumbosacral Radiculopathy (Sciatica) 

     Painful lumbosacral radiculopathy, commonly known as sciatica, is a specific kind of low back pain due to inflammation or pinching of a spinal nerve. It presents as electric, burning, and/or sharp pain in the lower back which may radiate into the legs. Researchers are currently investigating a method of targeting lumbosacral radiculopathy pain by preventing peripheral nerves from sending pain signals.   

     

    Jacksonville Center for Clinical Research is conducting a research study that will evaluate an investigational medication for Painful Lumbosacral Radiculopathy (sciatica). 

     

    You may be eligible to participate if you: 

    • Are 18-70 years old 
    • Are over 100 pounds with a BMI under 40 
    • Have been diagnosed with painful lumbosacral radiculopathy (sciatica) for at least 3 months; with leg pain worse than back pain 
    • Have not used opioids for chronic pain in the last 3 months or taken opioids for more than 7 days for acute pain in the past 3 months. 

     

    There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and medical exams at no cost, along with compensation for study-related time and reimbursement for travel. No health insurance is required to participate. 

     

    For more information call 

    (904) 730-0166 

    Or sign up below, and our friendly staff will call you! 

    Nature Coast Crystal River Study

     Painful Lumbosacral Radiculopathy (Sciatica) 

    Painful lumbosacral radiculopathy, commonly known as sciatica, is a specific kind of low back pain due to inflammation or pinching of a spinal nerve. It presents as electric, burning, and/or sharp pain in the lower back which may radiate into the legs. Researchers are currently investigating a method of targeting lumbosacral radiculopathy pain by preventing peripheral nerves from sending pain signals.   

     

    Nature Coast Clinical Research – Crystal River is conducting a research study that will evaluate an investigational medication for Painful Lumbosacral Radiculopathy (sciatica). 

     

    You may be eligible to participate if you: 

    • Are 18-70 years old 
    • Are over 100 pounds with a BMI under 40 
    • Have been diagnosed with painful lumbosacral radiculopathy (sciatica) for at least 3 months; with leg pain worse than back pain 
    • Have not used opioids for chronic pain in the last 3 months or taken opioids for more than 7 days for acute pain in the past 3 months. 

     

    There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and medical exams at no cost, along with compensation for study-related time and reimbursement for travel. No health insurance is required to participate. 

     

    For more information call 

    (352) 563-1865 

    Or sign up below, and our friendly staff will call you! 




      Lumbosacral Radiculopathy research is enrolling at:


      Nature Coast Clinical Research – Crystal River
      6122 West Corporate Oaks Drive
      Crystal River, FL 34429
      (352) 563-1865



      Fleming Island Center for Clinical Research
      1679 Eagle Harbor Parkway
      Suite D, 2nd Floor Fleming Island, FL 32003
      (904) 621-0390



      Jacksonville Center for Clinical Research
      4085 University Blvd., South
      Suite 1
      Jacksonville, FL 32216
      (904) 730-0166



      BELOW ARE HIDDEN ROWS

      Fleming Island Center for Clinical Research
      1679 Eagle Harbor Parkway
      Suite D, 2nd Floor Fleming Island, FL 32003
      (904) 621-0390



      Jacksonville Center for Clinical Research
      4085 University Blvd., South
      Suite 1
      Jacksonville, FL 32216
      (904) 730-0166



      St. Johns Center for Clinical Research
      100 Whetstone Place,
      Suites 300 – 301,
      St. Augustine, FL 32086

      (904) 209-0043



      ENCORE Borland Groover Clinical Research
      4800 Belfort Road, Suite 301
      Jacksonville, FL 32256
      (904) 680-0871



      Westside Center for Clinical Research
      810 Lane Avenue South
      Jacksonville, FL 32205
      (904) 693-1490



      Nature Coast Clinical Research – Inverness
      411 West Highland Boulevard
      Inverness, FL 34452
      (352) 341-2100



      Nature Coast Clinical Research – Crystal River
      6122 West Corporate Oaks Drive
      Crystal River, FL 34429
      (352) 861-1865



      Learn More

      If you want us to contact you about our research studies call (904) 730-0166 or sign up below!


      cactus.gout_.jpg

      August 11, 2023

      Gout is a painful and progressive form of arthritis. It is caused by a buildup of uric acid, which crystalizes inside of joints. This leads to inflammation, immune response, pain, and joint damage.

      For more information call

      (904) 730-0166



      • Jacksonville Gout Study
      • Crystal River Gout Study
      Jacksonville Gout Study

      Gout is a painful and progressive form of arthritis. It is caused by a buildup of uric acid, which crystalizes inside of joints. This leads to inflammation, immune response, pain, and joint damage.

      We are conducting a clinical research study for people who have gout. The purpose of this study is to evaluate the effectiveness and safety of an investigational medication for gout.

      You may be eligible if you:

      • Are 19 to 69 years old
      • Have been diagnosed with gout
      • Have a BMI of 18 to 40
      • Do not have rheumatoid arthritis or another autoimmune disease

      There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and medical exams at no cost, along with a stipend for time and travel. No health insurance is required to participate.

      For more information call

      (904) 730-0166

      Crystal River Gout Study

      Gout is a painful and progressive form of arthritis. It is caused by a buildup of uric acid, which crystalizes inside of joints. This leads to inflammation, immune response, pain, and joint damage.

      We are conducting a clinical research study for people who have gout. The purpose of this study is to evaluate the effectiveness and safety of an investigational medication for gout.

      You may be eligible if you:

      • Are 19 to 69 years old
      • Have been diagnosed with gout
      • Have a BMI of 18 to 40
      • Do not have rheumatoid arthritis or another autoimmune disease

      There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and medical exams at no cost, along with a stipend for time and travel. No health insurance is required to participate.

      For more information call

      (352) 563-1865



      Gout research is enrolling at:


      Jacksonville Center for Clinical Research
      4085 University Blvd., South
      Suite 1
      Jacksonville, FL 32216
      (904) 730-0166



      Nature Coast Clinical Research – Crystal River
      6122 West Corporate Oaks Drive
      Crystal River, FL 34429
      (352) 563-1865



      BELOW ARE HIDDEN ROWS

      Fleming Island Center for Clinical Research
      1679 Eagle Harbor Parkway
      Suite D, 2nd Floor Fleming Island, FL 32003
      (904) 621-0390



      Jacksonville Center for Clinical Research
      4085 University Blvd., South
      Suite 1
      Jacksonville, FL 32216
      (904) 730-0166



      St. Johns Center for Clinical Research
      100 Whetstone Place,
      Suites 300 – 301,
      St. Augustine, FL 32086

      (904) 209-0043



      ENCORE Borland Groover Clinical Research
      4800 Belfort Road, Suite 301
      Jacksonville, FL 32256
      (904) 680-0871



      Westside Center for Clinical Research
      810 Lane Avenue South
      Jacksonville, FL 32205
      (904) 693-1490



      Nature Coast Clinical Research – Inverness
      411 West Highland Boulevard
      Inverness, FL 34452
      (352) 341-2100



      Nature Coast Clinical Research – Crystal River
      6122 West Corporate Oaks Drive
      Crystal River, FL 34429
      (352) 861-1865



      Learn More

      If you want us to contact you about our research studies call (904) 730-0166 or sign up below!


      Heart-Failure.jpg

      July 22, 2021

      Heart failure is a serious medical condition where the heart cannot effectively deliver enough oxygenated blood to the organs. It affects millions of Americans and may have debilitating symptoms including edema, shortness of breath, systemic inflammation, and reduced quality of life. 


      For more information, call:

      (904) 730-0166 (Jacksonville)
      (904) 209-0043 (St. Augustine)
      (352) 563-1865 (Crystal River)
      (352) 341-2100 (Inverness)

      Click on the drop-down below to see the criteria for each location. 

      Or sign up below, and our office will call you!


      • Jacksonville – Study (BMS)
      • Jacksonville – Study (HERMES)
      • St. Augustine – Study (HERMES)
      • Crystal River – Study (HERMES)
      • Inverness – Study (BMS)
      Jacksonville – Study (BMS)

      Heart Failure with Reduced Ejection Fraction

      Heart failure is a condition where the heart can’t pump well enough to deliver oxygen to the organs effectively. Ejection fraction is a term used to describe the amount of blood pumped out compared with the total blood the heart can hold. In a healthy heart, 50-70% of blood is ejected with each heartbeat.

      We are conducting a clinical research study of a new investigational drug for people who have heart failure with a reduced ejection fraction.

      You may be eligible if you:

      • Are between 18 and 75 years old
      • Have heart failure
      • Have an ejection fraction (LVEF) of 15% to 45%
      • Are currently taking medication for heart failure

      Volunteers must be able to complete multiple overnight stays at our phase 1 clinic for this study. There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and study-related medical exams at no cost. A stipend of up to $4,334 is available for participants who complete the study. No health insurance is required to participate.

       

      For more information call

      (904) 730-0166

      Or sign up below, and our friendly staff will call you!

      Jacksonville – Study (HERMES)

      Heart Failure Clinical Research

      Heart failure is a serious medical condition where the heart cannot effectively deliver enough oxygenated blood to the organs. It affects millions of Americans and may have debilitating symptoms including edema, shortness of breath, systemic inflammation, and reduced quality of life.

      Even with the best available treatment, there is still a risk of serious complications. Reducing the amount of systemic inflammation may increase health outcomes for people with heart failure. We are conducting a research study for people with heart failure that will evaluate the effectiveness of an investigational drug on cardiovascular health outcomes.

      You may be eligible if you:

      • Are 18 or older
      • Have heart failure
      • Have a preserved or mildly reduced ejection fraction (LVEF >40%) documented by echocardiography within the past 12 months

      There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and study-related medical exams at no cost and a stipend for time and travel. No health insurance is required to participate.

       For more information call

      (904) 730-0166

      Or sign up below, and our friendly staff will call you!

      St. Augustine – Study (HERMES)

      Heart Failure Clinical Research

      Heart failure is a serious medical condition where the heart cannot effectively deliver enough oxygenated blood to the organs. It affects millions of Americans and may have debilitating symptoms including edema, shortness of breath, systemic inflammation, and reduced quality of life. Even with the best available treatment, there is still a risk of serious complications. Reducing the amount of systemic inflammation may increase health outcomes for people with heart failure. We are conducting a research study for people with heart failure that will evaluate the effectiveness of an investigational drug on cardiovascular health outcomes.

      You may be eligible if you:

      • Are 18 or older
      • Have heart failure
      • Have a preserved or mildly reduced ejection fraction (LVEF >40%) documented by echocardiography within the past 12 months

      There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and study-related medical exams at no cost and a stipend for time and travel. No health insurance is required to participate. 

      For more information call

      (904) 209-0043

      Or sign up below, and our friendly staff will call you!

      Crystal River – Study (HERMES)

      Heart Failure Clinical Research

      Heart failure is a serious medical condition where the heart cannot effectively deliver enough oxygenated blood to the organs. It affects millions of Americans and may have debilitating symptoms including edema, shortness of breath, systemic inflammation, and reduced quality of life. Even with the best available treatment, there is still a risk of serious complications. Reducing the amount of systemic inflammation may increase health outcomes for people with heart failure. We are conducting a research study for people with heart failure that will evaluate the effectiveness of an investigational drug on cardiovascular health outcomes.

      You may be eligible if you:

      • Are 18 or older
      • Have heart failure
      • Have a preserved or mildly reduced ejection fraction (LVEF >40%) documented by echocardiography within the past 12 months

      There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and study-related medical exams at no cost and a stipend for time and travel. No health insurance is required to participate. 

      For more information call

      (352) 341-2100

      Or sign up below, and our friendly staff will call you!

      Inverness – Study (BMS)

      Heart Failure with Reduced Ejection Fraction

      Heart failure is a condition where the heart can’t pump well enough to deliver oxygen to the organs effectively. Ejection fraction is a term used to describe the amount of blood pumped out compared with the total blood the heart can hold. In a healthy heart, 50-70% of blood is ejected with each heartbeat.

      We are conducting a clinical research study of a new investigational drug for people who have heart failure with a reduced ejection fraction.

      You may be eligible if you:

      • Are between 18 and 75 years old
      • Have heart failure
      • Have an ejection fraction (LVEF) of 15% to 45%
      • Are currently taking medication for heart failure

      Volunteers must be able to complete multiple overnight stays at our phase 1 clinic for this study. There are additional criteria to meet to qualify for this study. Volunteers who qualify for our study will receive study-related medication and study-related medical exams at no cost. A stipend of up to $4,334 is available for participants who complete the study. No health insurance is required to participate.

       For more information call

      (352) 341-2100

      Or sign up below, and our friendly staff will call you!



      This research is enrolling at:


      Jacksonville Center for Clinical Research
      4085 University Blvd., South
      Suite 1
      Jacksonville, FL 32216
      (904) 730-0166



      St. Johns Center for Clinical Research
      100 Whetstone Place,
      Suites 300 – 301,
      St. Augustine, FL 32086

      (904) 209-0043



      Nature Coast Clinical Research – Crystal River
      6122 West Corporate Oaks Drive
      Crystal River, FL 34429
      (352) 563-1865



      Nature Coast Clinical Research – Inverness
      411 West Highland Boulevard
      Inverness, FL 34452
      (352) 341-2100



      BELOW ARE HIDDEN ROWS

      Fleming Island Center for Clinical Research
      1679 Eagle Harbor Parkway
      Suite D, 2nd Floor Fleming Island, FL 32003
      (904) 621-0390



      Jacksonville Center for Clinical Research
      4085 University Blvd., South
      Suite 1
      Jacksonville, FL 32216
      (904) 730-0166



      St. Johns Center for Clinical Research
      100 Whetstone Place,
      Suites 300 – 301,
      St. Augustine, FL 32086

      (904) 209-0043



      ENCORE Borland Groover Clinical Research
      4800 Belfort Road, Suite 301
      Jacksonville, FL 32256
      (904) 680-0871



      Westside Center for Clinical Research
      810 Lane Avenue South
      Jacksonville, FL 32205
      (904) 693-1490



      Nature Coast Clinical Research – Inverness
      411 West Highland Boulevard
      Inverness, FL 34452
      (352) 341-2100



      Nature Coast Clinical Research – Crystal River
      6122 West Corporate Oaks Drive
      Crystal River, FL 34429
      (352) 861-1865



      Learn More

      If you want us to contact you about our research studies call (904) 730-0166 or sign up below!